5. Neurons/Synapses/Glia
penicillin is toxic to CNS neurons (blood-brain barrier prevents:
but infection allows meninges to absorb some
penicillin)
tetracyclines readily
cross blood brain barrier
Stains
1. Cresyl
violet: Nissl bodies = Rough ER; stains DNA and RNA
2. Golgi:
dendritic trees
3. Weigert:
stains lipid (myelinated axons) black
4. Pyradine:
stains neurofilaments (myelinated
and unmyelinated axons) black
Cell types
1. Neuron
- dendritic spines
- thin
= slower (young, retarded, etc.)
- axons have
mitochondria (no ribosomes)
- Golgi Type I:
long axons
- Golgi Type II:
short axons (interneurons)
- Synapses
- Gray’s Type I: asymmetric (excitatory):
- Gray’s Type II:
symmetric (inhibitory): glycine, GABA, ACh
2. Glia
a. Neuroglia = macroglia
i.
Astrocytes
- scars
in the CNS (found in MS patients)
ii. Oligodendrocytes
- myelination
b. Microglia
c. Macrophages
3. Other
a. endothelial cells