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American Journal of Clinical PathologyAmerican Journal of Surgical PathologyHuman PathologyJournal of Pathology (European)
Modern PathologyNew England Journal of Medicine

J Pathol., Jul 2011, Volume 224, Issue 3

The roles of fascins in health and disease.

Lessons from the deep study of rare tumours.

Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression.

The MYB-NFIB gene fusion-a novel genetic link between adenoid cystic carcinoma and dermal cylindroma.

Loss of BAF250a (ARID1A) is frequent in high-grade endometrial carcinomas.

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours.

The chemokine CXCL12 and its receptor CXCR4 promote glioma stem cell-mediated VEGF production and tumour angiogenesis via PI3K/AKT signalling.
J Pathol., Jun 2011, Volume 224, Issue 2

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

Myd88 deficiency influences murine tracheal epithelial metaplasia and submucosal gland abundance.

Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium.

Somatic mutation of fibroblast growth factor receptor-3 (FGFR3) defines a distinct morphological subtype of high-grade urothelial carcinoma.
J Pathol., May 2011, Volume 224, Issue 1

Re: Grotenhuis et al. Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers. J Pathol 2010; 221: 379-389.

Revisiting cancer immunoediting by understanding cancer immune complexity.

Development of metastatic HER2(+) breast cancer is independent of the adaptive immune system.
J Pathol., Apr 2011, Volume 223, Issue 5

Unveiling the molecular pathogenesis of chordoma: a new paradigm for molecular targeting of rare cancers.

Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas.

LMP1 antagonizes WNT/β-catenin signalling through inhibition of WTX and promotes nasopharyngeal dysplasia but not tumourigenesis in LMP1(B95-8) transgenic mice.

Elevation of WNT5A expression in polyp formation in Lkb1(+/-) mice and Peutz-Jeghers syndrome.

Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs.

Senescent mesenchymal cells accumulate in human fibrosis by a telomere-independent mechanism and ameliorate fibrosis through matrix metalloproteinases.

Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas.

Effects of targeting the VEGF and PDGF pathways in diffuse orthotopic glioma models.

Human embryonic stem cells rapidly take up and then clear exogenous human and animal prions in vitro.

Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.

Ski, a modulator of wound healing and scar formation in the rat skin and rabbit ear.

Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma.

PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21$^{{\rm Cip1}}$ signaling pathway.

List of reviewers.
J Pathol., Mar 2011, Volume 223, Issue 4

The Journal of Pathology's approach to publication ethics and misconduct.

Genetic changes in tumour microenvironments.

Fibroblast gene expression profile reflects the stage of tumour progression in oral squamous cell carcinoma.

Stromal features are predictive of disease mortality in oral cancer patients.

MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells.

Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling.

Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study.

The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.

Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders.

Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer.

Chronic chorioamnionitis displays distinct alterations of the amniotic fluid proteome.
J Pathol., Feb 2011, Volume 223, Issue 3

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.

Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8(+) T-lymphocyte infiltration and affect tumour progression.

Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

TNF-related apoptosis-inducing ligand cooperates with NSAIDs via activated Wnt signalling in (pre)malignant colon cells.

Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.

BCL2L10 protein regulates apoptosis/proliferation through differential pathways in gastric cancer cells.

Alcoholics show reduced telomere length in the oesophagus.

Activation of lung macrophage subpopulations in experimental acute pancreatitis.

Immunohistochemical expression of conjugating UGT1A-derived isoforms in normal and tumoral drug-metabolizing tissues in humans.

Pathology Quote #9:

"Science in itself is nothing, for it exists only in the human beings who are its bearers . . . the idea "science for its own sake" . . . recalls the non-human conception in which man regards his soul as the true reality, as his real essence, where he "knows himself only as a spirit and has yet come to value his corporeal part."

- Rudolf Virchow

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